Jean DUBUISSON

Virologie Moléculaire et Cellulaire de l’Hépatite C


Our team is dedicated to the study of positive-strand RNA viruses. Our main objectives are to better understand how these viruses interact with their host at the cellular and molecular level and to identify new antiviral target. Our viral models are hepatitis C virus (HCV), hepatitis E virus (HEV) and coronaviruses. For more than 20 years, our team has been studying the HCV life cycle and we have contributed to the field by characterizing the biogenesis of HCV glycoproteins as well as their functions in virus entry and assembly. We have also characterized host factors involved in different steps of the viral life cycle. We have also contributed to the characterization of HCV entry with the help of new antiviral molecules identified in our laboratory. Although major progress have been achieved since the development of a cell culture system for HCV in 2005, many gaps remain in our understanding of the HCV life cycle. We therefore continue to study this virus and more particularly its interaction with the lipid metabolism. In 2013, we have also decided to initiate a new project on the Middle East Respiratory Syndrome coronavirus (MERS-CoV). This emerging virus is life threatening and there is currently no specific antiviral available to treat infected patients. Our current objective is therefore to identify and characterize host factors involved in the life cycle of this virus and identify novel antiviral targets. From a more fundamental point of view, we are more interested to better understand the molecular mechanisms leading to virus assembly. More recently, due to the accumulation of tools to study HCV, we have also initiated a project on HEV, another hepatotropic virus, and we are also interested to identify and characterize host factors involved in the life cycle of this virus.

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