List of publications


Alard J, Lehrter V, Rhimi M, Mangin I, Peucelle V, Abraham AL, Mariadassou M, Maguin E, Waligora-Dupriet AJ, Pot B, Wolowczuk I and Grangette C. Beneficial metabolic effects of selected probiotics on diet-induced obesity and insulin resistance in mice are associated with improvement of dysbiotic gut microbiota. Environ Microbiol.; in press

Breton J, Daniel C, Vignal C, Body-Malapel M, Garat A, Plé C and Foligné B. 2016. Does oral exposure to cadmium and lead mediate susceptibility to colitis? The dark-and-bright sides of heavy metals in gut ecology. Scientific Reports. In press

Plé C, Breton J, Richoux R, Nurdin M, Deutsch SM, Falentin H, Hervé C, Chuat V, Lemée R, Maguin E, Jan G, Van de Guchte M and Foligné B. 2016. Combining selected immunomodulatory Propionibacterium freudenreichii and Lactobacillus delbrueckii strains: reverse engineering development of an anti-inflammatory cheese. Molecular Nutrition & Food Research. Accepted. 2015 Dec 7. doi: 10.1002/mnfr.201500580. [

Foligné B, Parayre S, Cheddani R, Famelart MH, Madec MN, Plé C, Breton J, Dewulf J, Jan G and Deutsch SM.. 2016. Immunomodulation properties of multi-species fermented milks. Food Microbiol. 53(Pt A):60-69.

Adouard N, Magne L, Cattenoz T, Guillemin H, Foligné B, Picque D and Bonnarme P. 2016. Survival of cheese-ripening microorganisms in a dynamic simulator of the gastrointestinal tract. Food Microbiol. 53(Pt A):30-40.

Jérôme M, Macé S, Dousset X, Pot B and Joffraud JJ. 2015. Genetic diversity analysis of isolates belonging to the Photobacterium phosphoreum species group collected from salmon products using AFLP fingerprinting. Int J Food Microbiol. 217:101-109.



Bindels LB, Neyrinck AM, Claus SP, Le Roy CI, Grangette C, Pot B, Martinez I, Walter J, Cani PD and Delzenne NM. 2015. Synbiotic approach restores intestinal homeostasis and prolongs survival in leukaemic mice with cachexia ISME J. 2015 Nov 27.

Vandoolaeghe S, Blaizot A, Boudiguet D, Valérie Bougault V, Dei Cas E, Foligné B, Goffard A, Lefranc H, Oxombre B, Trentesaux T, Vandenbunder B, Wolowczuk I and Delhaes L. 2015. A Charter for Biomedical Research Ethics in a Progressive, Caring Society. Philosophy, Ethics, and Humanities in Medicine. 10:12.

Plé C, Richoux R, Jardin J, Briard-Bion V, Parayre S, Ferreira S, Pot B, Deutsch SM, Falentin H, Jan G and Foligné B. 2015. Single-strain starter experimental cheese reveals anti-inflammatory effect of Propionibacterium freudenreichii CIRM BIA 129 in TNBS-colitis model. Journal of Functional Foods. 18: 575-585.

Daniel C, Poiret S, Dennin V, Boutillier D, Lacorre DA, Foligné B and Pot B. Dual color bioluminescence imaging for simultaneous monitoring of intestinal persistence of Lactobacillus plantarum and Lactococcus lactis in living mice. Appl Environ Microbiol. 81(16):5344-9.

Plé C, Breton J, Daniel C and Foligné B. 2015. Maintaining gut ecosystems for health: are transitory food bugs stowaways or part of the crew? Int J of Food Microbiol. 213:139-43.

Goubard A, Loiez C, Abe J, Fichel C, Herwegh S, Faveeuw C, Porte R, Cayet D, Sebbane F, Penet S, Foligné B, Desreumaux P, Saito H, Sirard JC, Simonet M and Carnoy C. Superantigenic Yersinia pseudotuberculosis induces the expression of granzymes and perforin by CD4+ T cells. Infection and Immunity. 83(5):2053-64.

Foligné B, Papadimitriou K, Zoumpopoulou G, Alexandraki V, Kazou M, Tsakalidou E and Pot B. 2015. Discovering probiotic microorganisms: in vitro, in vivo, genetic and omics approaches. Front. Microbiol. Review. 6:58

Papadimitriou K, Anastasiou R, Maistrou E, Plakas T, Papandreou NC, Hamodrakas SJ, Ferreira S, Supply P, Renault P, Pot B and Tsakalidou E. 2015. Acquisition through Horizontal Gene Transfer of Plasmid pSMA198 by Streptococcus macedonicus ACA-DC 198 Points towards the Dairy Origin of the Species. PLoS One. 2015 Jan 13;10(1):e0116337.

Yanokura E, Oki K, Makino H, Modesto M, Pot B, Mattarelli P, Biavati B and Watanabe K. Subspeciation of Bifidobacterium longum by multilocus approaches and amplified fragment length polymorphism: Description of B. longum subsp. suillum subsp. nov., isolated from the faeces of piglets. Systematic and Applied Microbiology 38(5):305-14.

De Bruyne K, Pot B and Pouseele H. 2015. Whole genome MLST analysis: a universal typing approach for bacteria with many advantages. Eurolab June 2015; 66-67.

Papadimitriou K, Pot Bruno and Tsakalidou E. 2015. How microbes adapt to a diversity of food niches. Current Opinion in Food Science, 2:29–35.

Adouard N, Foligné B, Dewulf J , Pot B, Bouix M, Picque D and Bonnarme P. 2015. In vitro characterization of the digestive stress response and immunomodulatory properties of microorganisms isolated from smear-ripened cheese, Int J of Food Microbiol. 197: 98–107

Plé C, Fan Y, Ait Yahia S, Vorng H, Everaere L, Chenivesse C, Balsamelli J, Azzaoui I, de Nadai P, Wallaert B, Lazennec G and Tsicopoulos A. Polycyclic aromatic hydrocarbons reciprocally regulate IL-22 and IL-17 cytokines in peripheral blood mononuclear cells from both healthy and asthmatic subjects. PLoS One. 2015 Apr 10;10(4):e0122372.

Plé C, Adouard N, Breton J, Dewulf J, Pot B, Bonnarme P and Foligné B. 2015. Designing specific cheese-ripening ecosystems to shape immune effects of dairy products? Journal of Functional Foods 12 219-229.

Le Maréchal C, Peton V, Plé C, Vroland C, Jardin J, Briard-Bion V, Durant G, Chuat V, Loux V, Foligné B, Deutsch SM, Falentin and Jan G. 2015. Surface proteins of Propionibacterium freudenreichii are involved in its anti-inflammatory properties. J Proteomics,113:447-61

Wattez JS, Delmont A, Bouvet M, Beseme O, Goers S, Delahaye F, Laborie C, Lesage J, Foligne B, Breton C, Metges C, Vieau D and Pinet F. Maternal perinatal undernutrition modifies lactose and serotranferin 1 in milk: relevance to the programming of metabolic diseases ? Am J Physiol Endocrinol Metab 308(5):E393-401.



Zacarías MF, Reinheimer J, Forzani L, Grangette C, Vinderola G. Mortality and translocation assay to study the protective capacity of Bifidobacterium lactis INL1 against Salmonella Typhimurium infection in mice. Benef Microbes. 2014 Dec;5(4):427-36.

Breton J, Plé C, Guerin-Deremaux L, Pot B, Lefranc-Millot C, Wils D, Foligné B. 2014. Intrinsic immunomodulatory effects of low-digestible carbohydrates selectively extend their anti-inflammatory prebiotic potentials. Biomed Research International. accepted

Le Maréchal C, Peton V, Plé C, Vroland C, Jardin J, Briard-Bion V, Durant G, Chuat V, Loux V, Foligné B, Deutsch SM, Falentin, Jan G. 2014. Surface proteins of Propionibacterium freudenreichii are involved in its anti-inflammatory properties. J Proteomics,113:447-61

Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B, Morelli L, Canani RB, Flint HJ, Salminen S, Calder PC, Sanders ME. 2014. Expert consensus document: The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol. 2014, 11(8):506-14.

Papadimitriou K, Anastasiou R, Mavrogonatou E, Blom J, Papandreou NC, Hamodrakas SJ, Ferreira S, Renault P, Supply P, Pot B, Tsakalidou E. 2014. Comparative genomics of the dairy isolate Streptococcus macedonicus ACA-DC 198 against related members of the Streptococcus bovis/Streptococcus equinus complex. BMC Genomics. 15:272.

Mattarelli P, Holzapfel W, Franz CM, Endo A, Felis GE, Hammes W, Pot B, Dicks L, Dellaglio F. 2014. Recommended minimal standards for description of new taxa of the genera Bifidobacterium, Lactobacillus and related genera. Int J Syst Evol Microbiol. 64(Pt 4):1434-51.

 Sanders ME, Lenoir-Wijnkoop I, Salminen S, Merenstein DJ, Gibson GR, Petschow BW, Nieuwdorp M, Tancredi DJ, Cifelli CJ, Jacques P, Pot B. 2014. Probiotics and prebiotics: prospects for public health and nutritional recommendations. Ann N Y Acad Sci. 1309:19-29.

Sanders ME, Klaenhammer TR, Ouwehand AC, Pot B, Johansen E, Heimbach JT, Marco ML, Tennilä J, Ross RP, Franz C, Pagé N, Pridmore RD, Leyer G, Salminen S, Charbonneau D, Call E, Lenoir-Wijnkoop I. 2014. Effects of genetic, processing, or product formulation changes on efficacy and safety of probiotics. Ann N Y Acad Sci. 2014 Feb;1309:1-18.

Wattez JS, Delahaye F, Barella LF, Dickes-Coopman A, Montel V, Breton C, Mathias P, Foligné B, Lesage J and Vieau D. 2014. Short- and long-term effects of maternal perinatal undernutrition are lowered by adoption during lactation in the male rat. J Dev Orig Health Dis. 5(2):109-20.

Kaci G, Goudercourt D, Dennin V, Pot B, Doré J, Ehrlich SD, Renault P, Blottière HM, Delorme C and Daniel C. 2014. Anti-inflammatory properties of Streptococcus salivarius a commensal bacterium of the oral cavity and digestive tract. Appl Environ Microbiol. 80(3): 928-934.


Breton J, Massart S, Vandamme P, De Brandt E, Pot B and Foligné B. 2013. Ecotoxicology inside the gut: impact of heavy metals on the mouse microbiome. BMC Pharmacology and Toxicology. 14(1):62.

Petschow B, Doré J, Hibberd P, Dinan T, Reid G, Blaser M, Cani PD, Degnan FH, Foster J, Gibson G, Hutton J, Klaenhammer TR, Ley R, Nieuwdorp M, Pot B, Relman D, Serazin A, Sanders ME. 2013. Probiotics, prebiotics, and the host microbiome: the science of translation. Ann N Y Acad Sci. 1306:1-17.

Hungin AP, Mulligan C, Pot B, Whorwell P, Agréus L, Fracasso P, Lionis C, Mendive J, Philippart de Foy JM, Rubin G, Winchester C, de Wit N; European Society for Primary Care Gastroenterology. 2013. Systematic review: probiotics in the management of lower gastrointestinal symptoms in clinical practice – an evidence-based international guide. Aliment Pharmacol Ther. 38(8):864-86.

Breton J, Daniel C, Dewulf J, Pothion S, Froux N, Sauty M, Thomas P, Pot B and Foligné B. 2013. Gut microbiota limits heavy metal burden caused by chronic oral exposure. Toxicol. Letters. 222(2):132-8.

Foligné B, Daniel C, Pot B. 2013. Probiotics from research to market: the possibilities, risks and challenges. Curr Opin Microbiol. 16(3):284-92.

Rahman A, Gleinser M, Lanhers MC, Riedel CU, Foligné B, Hanse M, Yen FT, Klouj A, Afzal M, Back A, Mangavel C, Cailliez-Grimal C, Revol-Junelles AM and Borges F. 2013. Survival of the psychrotrophic bacterium Carnobacterium maltaromaticum LMA 28 in the mice gastrointestinal tract, adhesion and immune consideration to human cells. International dairy Journal. 34:93-99.

Breton J, Le Clère K, Daniel C, Sauty M, Nakab L, Chassat T, Dewulf J, Penet S, Carnoy C, Thomas P, Pot B, Nesslany F, and Foligné B. 2013. Chronic ingestion of cadmium and lead alters the bioavailability of essential and heavy metals, gene expression pathways and genotoxicity in mouse intestine. Arch Toxicol. 87:1787-1795

Daniel C, Poiret S, Dennin V, Boutillier D and Pot B. 2013. Bioluminescence imaging study of spatial and temporal persistence of Lactobacillus plantarum and Lactococcus lactis in living mice. Applied Environ Microbiol. 79:1086-1094

Foligné B, Breton J, Mater D and Jan G. 2013. Tracking the microbiome functionality : focus on Propionibacterium species. Gut. 62:1227-1228



Grompone G, Martorell P, Llopis S, Gonzalez N, Genove s S, Paula Mulet A, Fernandez-Calero T, Tiscornia I, Bollati-Fogolin I, Chambaud I, Foligné B, Montserrat A, Ramon D. 2012. Anti-inflammatory Lactobacillus rhamnosus CNCM I-3690 strain protects against oxidative stress and increases lifespan in Caenorhabditis elegans. PlosOne 7(12): e52493.

Lemaître N, Ricard I, Pradel E, Foligné B, Courcol R, Simonet M and Sebbane F. 2012. Efficacy of ciprofloxacin-gentamicin combination therapy in murine bubonic plague. PlosOne 7(12): e52503.

Sedhom M, Pichery M, Murdoch J, Foligné B, Ortega N, Normand S, Mertz K, Sanmugalingam D, Brault L, Grandjean T, Lefrancais E, Fallo, O, Quesniaux V, Laurent Peyrin-Biroulet L, Cathomas, G, Junt T, Chamaillard M, Girard JP and B. Ryffel. 2012. Neutralization of IL-33/ST2 pathway ameliorates experimental colitis through enhancement of mucosal healing. Gut. 62(12):1714-23

Cousin FJ, Foligné B, Deutsch SM, Massart M, Parayre S, Le Loir Y, Boudry G and Jan G. 2012. Assessment of the probiotic potential of a dairy product fermented by Propionibacterium freudenreichii in piglets. J Agric Food Chem. 60(32):7917-27.

Kammoun H, Feunou Feunou P, Foligné B, Debrie AS, Raze D, Mielcarek N and Locht C. 2012. Dual mechanism of protection by live attenuated Bordetella pertussis BPZE1 against Bordetella bronchiseptica in mice. Vaccine. 30, 5864– 5870

Foligné B, Peys E, Vandenkerckhove J, Van hemel J, Dewulf J, Breton J and Pot B. 2012. Spores from two distinct colony types of the strain Bacillus subtilis PB6 substantiate anti-inflammatory probiotic effects in mice. Clin Nutr.. 31:987-994.

Cousin FJ, Deutsch SM, Perez Chaia A, Foligné B and Jan G. 2012. Interaction between probiotic dairy propionibacteria and the intestinal epithelium. Current Immunol. Rev. 8, 216-226.

Bindels LB, Beck R, Schakman O, Martin JC, De Backer F, Sohet FM, Dewulf EM, Pachikian BD, Neyrinck AM, Thissen JP, Verrax J, Calderon PB, Pot B, Grangette C, Cani PD, Scott KP and Delzenne NM. 2012. Involvement of gut lactobacilli in inflammation and muscle atrophy occurring in a mouse model of leukemia. PlosOne. in revision.

Deutsch SM, Parayre S, Bouchoux A, Guyomarc’h F, Dewulf J, Dols-Lafargue M, Baglinière F, Cousin FJ, Falentin H, Jan G and Foligné B. 2012. Contribution of surface β-glucan polysaccharide to physicochemical and immunomodulatory properties of Propionibacterium freudenreichii. Appl Environ Microbiol. 78(6):1765-75.

Papadimitriou K, Ferreira S, Papandreou NC, Mavrogonatou E, Supply P, Pot B and Tsakalidou E. 2012 Complete Genome Sequence of the Dairy Isolate Streptococcus macedonicus ACA-DC 198. J Bacteriol. 194 (7):1838-9.

Grangette, C. 2012. Bifidobacteria and subsets of dendritic cells: friendly players in immune regulation! Gut. 61(3):331-2.


Macho Fernandez E, Pot B and Grangette C. 2011. Beneficial effect of probiotics in IBD: are peptidogycan and NOD2 the molecular key effectors? Gut Microbes. 1: 2(5).

Grangette C, Macho Fernandez E and Pot B. 2011. Anti-inflammatory capacity of lactobacilli peptidoglycan: mucosal and systemic routes of administrations promote similar effects – The Authors’ reply. Gut. 61(5):784

Macho Fernandez E, Valenti V, Rockel C, Hermann C, Pot B, Boneca IG and Grangette C. 2011. Anti-inflammatory capacity of selected lactobacilli in experimental colitis is driven by NOD2-mediated recognition of a specific peptidoglycan-derived muropeptide. Gut. 60(8):1050-9.

Cousin FJ, Mater D, Foligné B and Jan G. 2011. Dairy propionibacteria as human probiotics: a review of recent evidences. Dairy Sci. Technol. 91(1):1-26.

Asteri IA, Papadimitriou K, Boutou E, Pot B, Vorgias CE and Tsakalidou E. 2011. Comparative and evolutionary analysis of plasmid pREN isolated from Lactobacillus rennini, a novel member of the theta-replicating pUCL287 family. Fems Microbiol. Letters, 318: 18-26.

Schwarzer M, Repa A, Daniel C, Schabussova I, Hrncir T, Pot B, Stepankova R, Hudcovic T, Pollak A, Tlaskalova-Hogenova H, Wiedermann U and Kozakova H. 2011. Neonatal colonization of mice with Lactobacillus plantarum producing the aeroallergen Bet v 1 biases towards Th1 and T-regulatory responses upon systemic sensitization. Allergy. 66(3):368-75

Daniel C, Roussel Y, Kleerebezem and Pot B. 2011. Recombinant lactic acid bacteria as mucosal biotherapeutic agents. Trends Biotechnol, 29(10): 499-508

Sanders ME, Heimbach JT, Pot B, Tancredi T, Lenoir-Wijnkoop I, Làhteenmãki-Uutela A, Gueimonde M and Banares S. 2011. Health claims substantiation for probiotic and prebiotic products. Gut Microbes. 2(3):1-7.

Asteri IA, E. Boutou E, Anastasiou R, Pot B, Vorgias CE, TsakalidouE and Papadimitriou K. 2011. In silico evidence for the horizontal gene transfer of gsiB, a σ(B)-regulated gene in Gram-positive bacteria, to lactic acid bacteria. Appl Environ Microbiol. 77(10):3526-31


Foligné B, Deutsch SM, Breton J, Cousin FJ, Dewulf J, Samson M, Pot B and Jan G. 2010. Promising immunomodulatory effects of selected strains of Propionibacterium freudenreichii evidenced in vitro and in vivo. Appl Environ Microbiol. 76: 8259-8264.

Del Rosario L, Pot B, Goris J et al. 2010. An automated workflow for high throughtput MLVA using the BioNumerics (R) software, able to deal with varying experimental. Int. J. Infect. Dis. 14:E360-E361.

Asteri IA, Papadimitrio K, Boutou E, Anastasiou R, Pot B, Vorgias CE and Tsakalidou E. 2010. Characterization of pLAC1, a cryptic plasmid isolated from Lactobacillus acidipiscis and comparative analysis with its related plasmids. Int. J. Food Microbiol. 141:222-228.

O’Flaherty S, Saulnier DM, Pot B and Versalovic J. 2010. How Can Probiotics and Prebiotics Impact Mucosal Immunity? Gut Microbes. 1:5, 1-8.

 De Vuyst L, Vincent P, Makras E, Leroy F and Pot B. 2010. Peptide Extracts from Cultures of Certain Lactobacilli Inhibit Helicobacter pylori. Probiotics and Antimicro. Prot. 2:26-36.

Foligné B, Dewulf J, Vandekerckove P, Pignede G and Pot B. 2010. Probiotic yeasts: anti-inflammatory potential of various non-pathogenic strains in experimental colitis in mice. World J Gastroenterol. 7; 16:2134-2145.

Foligné B, Dewulf J, Breton J, Claisse O, Lonvaud-Funel A and Pot B. 2010. Probiotic properties of non-conventional lactic acid bacteria: Immunomodulation by Oenococcus oeni. Int. J. Food Microbiol. 140:136-145

Mattocks C, Watkins G, Ward D, Janssens T, Bosgoed E, van der Donk K, Ligtenberg M, Pot B, Theelen J, Cross N, Scheffer H and Matthijs G. 2010. Inter-laboratory Diagnostic Validation of Conformation Sensitive Capillary Electrophoresis for Mutation Scanning. Clin. Chem. 56 (4):593-602.


Pirnay JP, Bilocq F, Pot B, Cornelis P, Zizi M, Van Eldere J, Deschaght P, Vaneechoutte M, Jennes S, Pitt T, De Vos D. 2009. Pseudomonas aeruginosa Population Structure Revisited. PLoS One. 13: e7740

Rigaux P, Daniel C, Hisbergues M, Muraille E, Hols P, Pot B, Pestel J and Jacquet A. 2009. Immunomodulatory properties of Lactobacillus plantarum and its use as a recombinant vaccine against mite allergy. Allergy. 64 p 406-414.

Foligné B, Pot B. 2009. Comment on “Some immunomodulatory effects of probiotic bacteria might be due to porcine neutrophil elastase inhibitor, a serpin present in MRS broth”. Immunol. Lett.122: 227-228.

Zoumpopoulou G; Tsakalidou E; Dewulf J, Pot B and Grangette C. 2009. Differential crosstalk between epithelial cells, dendritic cells and bacteria in a co-culture model. Int. J. Food Microbiol. 13: 40-51

Heuvelin E, Lebreton C, Grangette C, Pot B, Cerf-Bensussan N and Heyman M. 2009. Mechanisms Involved in Alleviation of Intestinal Inflammation by Bifidobacterium Breve Soluble Factors. PloS One. 4 (4):e5184.

Daniel C, Sebbane F, Poiret S, Goudercourt D, Dewulf J, Mullet C, Simonet M and Pot B. 2009. Protection against Yersinia pseudotuberculosis infection conferred by a Lactococcus lactis mucosal delivery vector secreting LcrV. Vaccine. 27 :1141-1144.

Book chapters

Benjamin Felix, Sophie Roussel, Bruno Pot. 2015. Harmonization of PFGE profile analysis by using bioinformatics tools: example of the Listeria monocytogenes European Union Reference Laboratory network. P 9-28. In: Pulse Field Gel Electrophoresis: Methods and Protocols, Kieran Jordan and Marion Dalmasso (Eds). Methods in Molecular Biology series, 1301, John M. Walker (Ed). Humana Press, Springer Protocols.

Grangette, C. 2011. Probiotiques et régulation de la réponse immunitaire : impact sur les maladies allergiques et inflammatoires intestinales. In Phytothérapie, Edited by Springer-Verlag, France

Grangette, C. 2010. Probiotics and Inflammatory Immune Responses. In Dietary Supplements and Immune Function, Edited by Watson RR, Zibadi S, Preedy V, Humana Press and Springer, p625-657

Pot B, Tsakalidou E. 2009. Taxonomy and metabolism of Lactobacillus. Chapter 2 In: Lactobacillus Molecular Biology. Edited by: Ljungh and Wadstrom, 2009, Caister Academic press, p 3-58.

Daniel, C. and Roussel Y. 2009. Bactéries lactiques utilisées comme vecteurs de délivrance de molécules vaccinales et thérapeutiques aux voies muqueuses. Chapitre VI du livre «Bactéries Lactiques, Physiologie, Métabolisme, Génomique et Applications Industrielles», p 521-539, Edition Economica sous la direction de Djamel Drider et Hervé Prévost.

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